The body provides many functions to make a person go through the day. From the body’s own metabolism to the endocrine system all the way to the microscopic level of cells, the body needs all of them to be functional. But when there are unwanted pathogens that are affecting the body, it can cause chronic illnesses to develop over time and cause the individual to be miserable. All is not lost as there are many ways to help dampen the effects of these chronic illnesses through the usage of peptide therapy. In this 2 part series, we will be taking a look at how the endocrine system and the body’s metabolism work together, what is metaflammation and its symptoms, and what is peptide’s role in the body. In part 2, we will be taking a look at what is peptide therapy and the different amino acids that can help the body. Peptide therapy is one of the many functional therapies that can help the body system when dealing with chronic issues that the person is dealing with. By referring patients to qualified and skilled providers who specialized in hormone wellness services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
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How Does Your Metabolism Affect Your Health?
The body’s metabolism is a chemical process where it provides energy to all the body’s functions through nutritious food and drinks. The sum total of all the chemical reactions is driving on how a person is feeling today and creating the chemistry moving that individual towards future health. Research shows that the body’s metabolism needs to naturally regulate itself in order to meet the body’s needs and wants. When a person has an endocrine disorder it can cause their body’s metabolism to be slower and develop health problems like obesity and metabolic syndrome.
The Endocrine System and Metabolism
The endocrine system and the body’s metabolism work together to make sure that the body is doing its job properly. The endocrine system is where several organs known as glands are located all over the body and help create and secrete hormones to be bonded into the bloodstream to be transported to the various organ systems and make sure that they are doing their jobs. The endocrine system goes through a process known as homeostasis, and it can affect many of the body’s functions including the body’s metabolism. Studies have found that when there are changes in the extra- and intracellular pH in the body, it can affect the metabolic states and hormone response. When that happens, the body will go through a dysfunctional change and it can disrupt the signals over time causing inflammation or even metaflammation.
What Is Metaflammation?
Also known as “Inflammageing” and metabolism-induced inflammation, metaflammation is a chronic low‐grade inflammatory sequela that increases the aging processes and metabolic signaling issues in individuals. It can be caused by and leads to “diabesity”, which is a combination of type 2 diabetes and obesity. Studies have found that metaflammation is a chronic, low-grade inflammatory state from the response of the metabolic cell to have an excess amount of nutrients that can contribute to the development of type 2 diabetes and increase insulin resistance in the peripheral tissues in the body. Other factors that metaflammation causes the body to be dysfunctional include:
- Chronic stress
- A poor diet
- LPS induced
- Liver/kidney issues
Since inflammation is an essential part of the body, it helps the body to be protected from pathogens, promoting healing and repairing damaged tissues. But when there are chronic illnesses that help transform acute inflammation into chronic inflammation it can cause serious harm to the body. Studies have shown that metaflammation can increase the conditions of chronic diseases and can become an unfavorable condition that promotes further tissue injury in the long term. The results in co‐morbid conditions from metaflammation include:
- Altered methylation patterns
- Cardiovascular issues – lipid, vascular
- Hormonal imbalances
- Liver and kidney diseases
- Immune dysfunction
- Sleep problems
- Cognitive and mood problems
What Are Peptides Role In The Body?
Peptides in the body are essential for the body as they play a fundamental physiological process. Research shows that peptides are named based on the number of amino acid residues that are in the peptide sequence. The entire body needs peptides since it is a hormone and it can help transport and store small molecules into the body. Peptides are enzymatic catalysts that can help control the growth and differentiation of hormones. What they do is that peptides help coordinate motion via muscle contraction, provide mechanical support from fibrous protein, generate and transmission of nerve impulses. Peptides can also provide the immune system protection by creating antibodies to battle against unwanted pathogens that enter the body and cause chronic illnesses to develop over time.
By making sure that the endocrine system and the body’s metabolism are working properly and functioning normally, the body can continue to functions its systems and live longer. When there are pathogens harming the body’s system and causing chronic inflammation or illnesses, then the body will have to suffer from the effects of the pathogens. Using functional therapy, like peptide therapy for the body, can provide beneficial results to individuals that are suffering from chronic pathogens like inflammation to relieve the symptoms and continue on their wellness journey.
Forbes, Jessica, and Karthik Krishnamurthy. “Biochemistry, Peptide.” StatPearls [Internet]., U.S. National Library of Medicine, 1 Sept. 2021, www.ncbi.nlm.nih.gov/books/NBK562260/.
Inoue, Y, and T Kaneko. “[Effects of Ph on the Endocrine System and Metabolism].” Nihon Rinsho. Japanese Journal of Clinical Medicine, U.S. National Library of Medicine, 1992, pubmed.ncbi.nlm.nih.gov/1434002/.
Kanbay, Mehmet, et al. “A Journey from Microenvironment to Macroenvironment: The Role of Metaflammation and Epigenetic Changes in Cardiorenal Disease.” Clinical Kidney Journal, Oxford University Press, 18 Sept. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6885688/.
Kuryłowicz, Alina, and Krzysztof Koźniewski. “Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes.” Molecules (Basel, Switzerland), MDPI, 9 May 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7249034/.
Medical Professionals, Cleveland Clinic. “Endocrine System: What Is It, Functions & Organs.” Cleveland Clinic, 12 May 2020, my.clevelandclinic.org/health/articles/21201-endocrine-system.
Medical Professionals, Cleveland Clinic. “Metabolism: What It Is, How It Works and Disorders.” Cleveland Clinic, 30 Aug. 2021, my.clevelandclinic.org/health/body/21893-metabolism.
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The information herein on "Looking At Peptide Therapies In Endocrine Restoration | Part 1" is not intended to replace a one-on-one relationship with a qualified health care professional, or licensed physician, and is not medical advice. We encourage you to make your own healthcare decisions based on your research and partnership with a qualified healthcare professional.
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Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*
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