The cardiovascular system‘s main role is to make sure that blood is pumping from the heart to all over the rest of the body through the veins and arteries. The blood cells are transporting oxygen, hormones, and nutrients to each of the organ systems. From the gut to the brain to the endocrine system, they need these blood cells to do their jobs properly. When there are disruptors that can affect the body, especially the cardiovascular system it can do some serious damage by conducting cardiovascular diseases to develop over time and cause the body pain. In this article, we will be taking a look at the difference between precision and personalized medicine for cardiovascular disease, the genetics, and genomics of CVD, as well as looking at how glutathione helps reduce CVD. By referring patients to qualified and skilled providers who specialized in cardiovascular services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
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What Is The Difference Between Personalized & Precision Medicine?
So personalized medicine is actually a medical model that separates people into different groups, which includes medical decisions, practices, interventions, and/or products that are being tailored to the individual patient based on their predicted response or risk of disease. Research studies showed that personalized medicine for cardiovascular disease is an emerging concept that can help manage an individual’s symptoms and even provide guidance for selecting treatments. Since cardiovascular disease still remains one of the leading causes of death, by focusing on the research and treatment, the individual is there with their healthcare provider to make the decisions. Other research studies have shown that personalized medicine treatment for cardiovascular disease is tailored to the individual with all the decisions and practices to not only treat cardiovascular disease but to figure out what is the best course of action to treatment.
Precision Medicine For Cardiovascular Disease
Precision Medicine is where medical care is designed to optimize efficiency or therapeutic benefit for particular groups of patients, especially by using genetic or molecular profiling. Surprisingly though, studies have stated that precision medicine has a more integrative approach to cardiovascular disease prevention and treatment by looking into the individual’s exposure to their cardiovascular health as determinants, while also finding strategies to improve cardiovascular health and preventing chronic diseases from rising in the body.
The Genetics Of Cardiovascular Disease
Since cardiovascular disease is a range of conditions that can cause problems to the cardiovascular system and the body, it is important to figure out the DNA sequence and the genes to cardiovascular disease. Research shows that discovering the genes for cardiovascular disease by looking at the linking analysis and the genetic association of cardiovascular disease. By correlating and identifying the specific genes as well as the DNA sequence to any chronic diseases that affect the body can give healthcare providers the results they need. Since reduction and prevention of chronic heart disease are not likely to improve without using genetic markers and gene expression testing to identify these pathways.
Since over 60% of the chronic heart disease risk, variants mediate risk independent of traditional known risk factors with unknown mechanisms or pathways. 40% overlap with genomic loci with classical risk factors. The three most frequently found loci are:
- 9p21.3 (epigenetic gene regulation- noncoding RNA to induce CHD.
- 6p24.1. (CHD in Chinese and Singapore and DVT)
- 1p13.3 (affects LDL-C).
Other research studies have shown that by searching the genes that are being predisposed to cardiovascular disease, health care professionals can identify the common DNA types in human variations for cardiovascular disease and start to contribute to preventing cardiovascular diseases while providing therapeutic measures.
How Does The Genomics Play In Cardiovascular Disease?
Research shows that by identifying the DNA regions that have been predisposed or the cause of cardiovascular disease. By looking at the DNA sequence, it can help clinicians to detect the phenotype of cardiovascular disease. The best yield of genome-wide association studies (GWAS) the pathways that underlie causes of CVD/CHD such as inflammation, oxidative stress, and immunologic vascular dysfunction. Looking at how different pathways are being affected by cardiovascular disease in the body is useful in trying different therapeutic ways of lowering the effects of chronic illnesses that are damaging the arteries in the cardiovascular system.
Oxidative Stress & Cardiovascular Disease
When there is an imbalance of ROS (reactive oxygen species) in the body due to oxidative stress and cardiovascular disease, the body will deal with many chronic symptoms that can damage the cellular structure. Research studies show that when there are excess amounts of ROS in the body it can damage the DNA molecules, lipids, and proteins causing necrosis and apoptotic cell death. When this happens the body will develop chronic inflammation and endothelial dysfunction, which are contributors to cardiovascular disease.
HCTP (human cellular tissue products) or stem cells* are a form of regenerative medicine that helps boost the body’s own natural healing process. Both international and nationally affiliated clinics and distribution organizations use HCTP as therapeutic treatments for individuals that are dealing with chronic pain in their bodies. HCTP is used to help repair and regenerate damaged cells, diseased tissues, and organs back to their original state and function so individuals can be pain-free.
Glutathione & Cardiovascular Disease
When the body has been affected by cardiovascular disease, the complications from the cardiovascular system will cause enhanced levels of free radicals that will cause impaired redox homeostasis. Research shows that the role of glutathione can help reduce oxidative stress in the body with its antioxidant properties. The GLUL gene on chromosome 1q25 increases chronic heart disease in diabetes mellitus by reducing the expression of glutamine synthase which converts glutamic acid to glutamine. The heart needs the effects of glutathione to preserve the redox homeostasis from cardiovascular disease while also regulating oxidative stress and reductive stress in the body.
All in all, finding ways to prevent cardiovascular disease from rising in the body is highly important for anyone that wants to start on their wellness journey. Getting a routine check-up from healthcare providers, eating nutritious foods that are beneficial to the heart, exercising regularly, and taking nutraceutical supplements that help the body can provide amazing results in dampening chronic illnesses. Taking these small steps can help a person be pain-free and continue to live life to the fullest.
Abbate, Rosanna, et al. “Genetics of Cardiovascular Disease.” Clinical Cases in Mineral and Bone Metabolism: the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, CIC Edizioni Internazionali, Jan. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2781194/.
Bajic, Vladan P, et al. “Glutathione ‘Redox Homeostasis’ and Its Relation to Cardiovascular Disease.” Oxidative Medicine and Cellular Longevity, Hindawi, 9 May 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6532282/.
Kathiresan, Sekar, and Deepak Srivastava. “Genetics of Human Cardiovascular Disease.” Cell, U.S. National Library of Medicine, 16 Mar. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3319439/.
Lee, Moo-Sik, et al. “Personalized Medicine in Cardiovascular Diseases.” Korean Circulation Journal, The Korean Society of Cardiology, Sept. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3467440/.
Leopold, Jane A, and Joseph Loscalzo. “Emerging Role of Precision Medicine in Cardiovascular Disease.” Circulation Research, U.S. National Library of Medicine, 27 Apr. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6021027/.
Roberts, Robert, et al. “Genomics in Cardiovascular Disease.” Journal of the American College of Cardiology, U.S. National Library of Medicine, 21 May 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3683584/.
Senoner, Thomas, and Wolfgang Dichtl. “Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?” Nutrients, MDPI, 4 Sept. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6769522/.
Tada, Hayato, et al. “Personalized Medicine for Cardiovascular Diseases.” Journal of Human Genetics, U.S. National Library of Medicine, 8 Aug. 2020, pubmed.ncbi.nlm.nih.gov/32772049/.
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