Dr. Alex Jimenez, El Paso's Chiropractor
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The Role of Dysbiosis and Thyroid Function

 Dysfunction of the immune system is the common denominator of diseases like Grave’s disease (GD), Hashimoto’s disease (HD), and celiac disease (CD). In addition, we can add Non-celiac wheat sensitivity to this equation. Furthermore, gut permeability caused by a damaged intestinal barrier can increase the passage of multiple pathogens. In turn, this phenomenon could result in an exacerbates immune reaction. Dysbiosis is also a common denominator of these conditions. A change in gut microbiota composition strongly influences micronutrient absorption and inflammation, affecting thyroid function.

Intestinal microbiota

Humans exist in symbiosis with our gastrointestinal bacteria. Nutrition, breastfeeding, birth modality, disease, medication, and stress can influence and change our gut microbiota, creating dysbiosis throughout our life. 

In terms of micronutrients, gut bacteria play a modulating role in synthesizing vitamins like vitamin K, Vitamin B2, B3, B5, B6, B7, B12, and folic acid. Consequently, dysbiosis can influence the apparition of immune, digestive and mental disorders.

Gut-associated lymphatic tissue

Microbiota influences the development of the gut-associated lymphatic tissue (GALT). Furthermore, GALT contains more than 70% of the entire immune system, controlling the tolerance of self-antigens.

Regulatory T-cells (Tregs) are critical modulators of the immune response, and their number increases in the presence of elevated levels of short-chain fatty acids (SCFA). These SCFA promote the growth of healthy bacteria and are derived from dietary fiber, which shows the strong influence of nutrition and microbiota. In addition, higher levels of SCFA can lower the concentration of pro-inflammatory Th-17 cells and strengthen the tight junctions.

Common signs of immunodeficiency like reduction of T-helper cells and Treg differentiation are part of celiac disease, HT, and GD. Furthermore, this phenomenon is associated with bacterial overgrowth and increased intestinal permeability, reflecting elevated pro-inflammatory cells and a harmful impact on thyroid function.

Enzymatic conversion of T4 to T3 has also been located in the intestinal wall. Although this has only been studied in rats, it shows that microbiota can bind thyroid hormones.

Celiac disease and Non-celiac wheat sensitivity

Wheat consumption, specifically gliadin protein in gluten-containing products, promotes a CD4+ Tcell-mediated cascade. Following this first reaction, an elevation in cytokines promotes an inflammatory response leading to CD8 +T cells activation, destroying inflamed enterocytes. Furthermore, this action triggers B-cell that produce antibodies against gliadin, transglutaminase, and endomysium. This cascade ends up in an increased intestinal mucosa inflammation, villous atrophy resulting in malabsorption, intestinal permeability, and increased gastrointestinal discomfort.

On the other hand, and without the autoimmune feature, non-celiac wheat sensitivity (NCWS) can cause similar symptoms to those in celiac disease. Nevertheless, NCWS has an immune-related response coming from the innate immune system. Studies have shown increased activation of Toll-like receptors (TLR) and inflammatory markers like TNF-A occurring with NCWS.

Some of the nutrient absorption affected by these conditions are iron, vitamin D, and selenium. These nutrients are crucial for thyroid function. 

Zonulin

In addition, the affected gut’s permeability leads to the penetration of pathogens to the immuno-reactive subepithelium, leading to autoimmunogenesis and inflammation. Zonulin plays the role of gut permeability modulator and can weaken the tight junctions of the intestinal barrier.

 

Autoimmune diseases are complex conditions with a common gastrointestinal feature. The role of gut permeability and dysbiosis can promote autoimmunogenesis and inflammation add up to the issue, promoting a situation that might be hard to control. In addition, the micronutrient deficiency promoted by the interaction of these mechanisms affects thyroid function and hormone synthesis. Functional or orthomolecular medicine provides a complete treatment by testing and not guessing. If all diseases start in the gut, treating dysbiosis, renewing and repairing the gut lining is the first thing we need to target.- Ana Paola Rdz. Arciniega, MS

References:

Knezevic, Jovana et al. “Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?.” Nutrients vol. 12,6 1769. 12 Jun. 2020, doi:10.3390/nu12061769

Additional Online Links & Resources (Available 24/7)

 

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Online Physical Injury / Accident Intake Form: bit.ly/Fill-Out-Your-Online-History 

 

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Disclaimer

 

The information herein is not intended to replace a one-on-one relationship with a qualified healthcare professional, licensed physician, and not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and issues that relate to and support, directly or indirectly, our clinical scope of practice.* 

Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900. Read More.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG*

email: coach@elpasofunctionalmedicine.com

phone: 915-850-0900

Licensed in Texas & New Mexico

Post Disclaimer

Professional Scope of Practice *

The information herein on "The Role of Dysbiosis and Thyroid Function" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
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Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training, and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists, and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

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Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, unwanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

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Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form:  bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment:  bit.ly/functionmed

Disclaimer *

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

phone: 915-850-0900

Licensed in Texas & New Mexico *

Dr. Alex Jimenez DC, MSACP, CIFM, IFMCP, ATN, CCST
My Digital Business Card

Post Disclaimer

Professional Scope of Practice *

The information herein on "Can Core Exercises Help with Back Pain? | El Paso, Tx (2023)" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card