Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Neuronal Connections and the Chemoaffinity Hypothesis

Neurons are believed to establish neuronal connections through innate predetermined programs during the developmental process of the brain. It’s also believed that neurons gravitate to areas of attraction and move away from areas of repulsion in a theory known as the chemoaffinity hypothesis. The Chemoaffinity hypothesis claims that neurons first make connections with their targets based on interactions with specific molecular markers and, therefore, that the first wiring diagram of an organism is indirectly determined by its genotype.

 

These markers are created during cellular differentiation and aid not just with synaptogenesis, but also act as guidance cues for their individual axon. The development of the mature nervous system formations demands axons to navigate to their correct targets in order to establish neuronal connections or synaptic connections. Growing axons create highly motile structures, known as growth cones, which direct the axon to its goal. They do it by responding to specific guidance molecules that either attract or repel the growth cone.

 

The Theory of Neuronal Connections

 

The concept that axons are directed principally by molecular determinants, rather than mechanical determinants, such as cells, extracellular material and other neurons, was established by Roger Wolcott Sperry, a neuropsychologist and neurobiologist, in 1963. However, it was not until the discovery of guidance molecules including netrins, semaphorins, ephrins and Slits, that Sperry’s chemoaffinity hypothesis became widely recognized as a prevalent mechanism for guidance of not only axons, but of all cells.

 

In 1981, Roger Sperry received the Nobel Prize for Physiology or Medicine for his discoveries concerning the functional specialization of the cerebral hemispheres. He performed studies on patients with epilepsy in whom the corpus callosum, or the bundle of axons fibers which connects the two brain hemispheres, was severed to stop seizures. A number of tests and evaluations revealed the way both brain hemispheres hold independent streams of conscious awareness, perceptions, thoughts and memories, and most fundamentally, that neuronal connections are formed and preserved with a high degree of precision.

 

Having demonstrated that the institution of specific neuronal connections is fundamental to the overall function of the brain, Sperry turned to look at how these connections are created, and used his chemoaffinity theory to describe how axons find the right target during the development of the brain. Others had raised the possibility that compound determinants might function in axon guidance, but it was Sperry that supplied the direct histological evidence and proposed the chemoaffinity hypothesis for axon guidance.

 

Roger Sperry and his Chemoaffinity Hypothesis

 

Roger Wolcott Sperry pioneered the inception of the Chemoaffinity Hypothesis after the 1960’s in a series of elegant experiments employing the retinotectal system of the African Clawed Frog, he sectioned the optic nerves and steered the eyes 180 degrees. He wished to know whether vision would be ordinary following regeneration or if the animal would eternally see the world ‘upside down’. If the latter held true, this could reveal that the nerves were somehow guided back to their original sites of termination; however, restoration of normal eyesight would mean that the nerves had resumed at new sites. Sperry showed that these creatures did indeed view the world ‘upside down’.

 

 

According to the experiment, initial eye orientation gives that the top of the eye is Dorsal, and the underside is Ventral. Post-operation, the “top” of the eye is now Ventral, and the base is Dorsal. After a food source was supplied, the frog extended its tongue, meaning that the Dorsal-Ventral orientation of the eye still remained. In follow up experiments, the eye was dispersed and rotated 180° and the optic nerve was also cut to determine if this could affect the Dorsal-Ventral orientation. The results were identical. It was those studies which directed Sperry to suggest that complicated chemical codes, under genetic control, direct axons to their targets, his chemoaffinity hypothesis.

 

In his first theory, Sperry proposed that distinct cells bear different cell-surface proteins that serve as markers, a notion that demanded an unsatisfactorily high variety of proteins. He revised his model suggesting that double gradients of guidance cues in the afferent and target areas would enable proper axon targeting. There is now extensive experimental data to support the chemoaffinity hypothesis, as well as the requirement for gradients of receptor and/or ligand, such as ephrins and Eph receptors, in the projection and target regions is well established.

 

Roger Wolcott Sperry concluded that every individual optic nerve and tectal neuron used some kind of chemical markers that dictated their connectivity through development. He concluded that if the eye had been rotated, each optic fiber and every tectal neuron possessed cytochemical labels that uniquely denoted their neuronal kind and place and that optic fibers may use these labels to navigate to their own matching target cell, hence the visuomotor impairment. Although certain aspects and details about Sperry’s model are unproven or incorrect, the basic notion of this chemoaffinity hypothesis has become dogma in developmental neurobiology.

 

Dr-Jimenez_White-Coat_01.png

Dr. Alex Jimenez’s Insight

Over the years, the principle to understand the establishment of neuronal connections has continued throughout the field of neurophysiology as well as prenatal development of the brain. Neuronal connections are believed to be established during the migration of growth cones guided by extracellular guidance cue gradients. Although this theory has been revisited countless of times, Roger Sperry was the first to explain how axons navigate to their correct targets in his chemoaffinity hypothesis. Countless experimental and clinical data now exists to support the chemoaffinity hypothesis.

 

The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .

 

Curated by Dr. Alex Jimenez

 

Green-Call-Now-Button-24H-150x150-2-3.png

 

Additional Topics: Sciatica

Sciatica is medically referred to as a collection of symptoms, rather than a single injury and/or condition. Symptoms of sciatic nerve pain, or sciatica, can vary in frequency and intensity, however, it is most commonly described as a sudden, sharp (knife-like) or electrical pain that radiates from the low back down the buttocks, hips, thighs and legs into the foot. Other symptoms of sciatica may include, tingling or burning sensations, numbness and weakness along the length of the sciatic nerve. Sciatica most frequently affects individuals between the ages of 30 and 50 years. It may often develop as a result of the degeneration of the spine due to age, however, the compression and irritation of the sciatic nerve caused by a bulging or herniated disc, among other spinal health issues, may also cause sciatic nerve pain.

 

 

 

blog picture of cartoon paperboy big news

 

EXTRA IMPORTANT TOPIC: Sciatica Pain

 

 

 MORE TOPICS: EXTRA EXTRA: El Paso, Tx | Athletes

 
 
Post Disclaimer

Professional Scope of Practice *

The information herein on "Neuronal Connections and the Chemoaffinity Hypothesis" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card

Again  We Welcome You¸

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training, and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists, and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, unwanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING!

Welcome & God Bless

EL PASO LOCATIONS

East Side: Main Clinic*
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677

Central: Rehabilitation Center
6440 Gateway East, Ste B
Phone: 915-850-0900

North East Rehabilitation Center
7100 Airport Blvd, Ste. C
Phone: 915-412-6677

Dr. Alex Jimenez DC, MSACP, CIFM, IFMCP, ATN, CCST
My Digital Business Card

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone
: (915) 850-0900
EmailSend Email
WebDrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
EmailSend Email
WebElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
EmailSend Email
WebChiropracticScientist.com

Just Play Fitness & Rehab*

Address: 7100 Airport Blvd, Suite C
El Paso, TX 79906
Phone: (915) 850-0900
EmailSend Email
WebChiropracticScientist.com

Push As Rx & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone
: (915) 412-6677
EmailSend Email
WebPushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone
: (915) 412-6677
EmailSend Email
WebPushAsRx.com

EVENTS REGISTRATION: Live Events & Webinars*

(Come Join Us & Register Today)

Call (915) 850-0900 Today!

Rated Top El Paso Doctor & Specialist by RateMD* | Years 2014, 2015, 2016, 2017, 2018, 2019, 2020 & 2021

Best Chiropractor In El Paso

Scan QR Code Here - Connect Here With Dr. Jimenez Personally

Qrcode Chiropractor
Dr. Jimenez QR Code

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form:  bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment:  bit.ly/functionmed

Disclaimer *

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

phone: 915-850-0900

Licensed in Texas & New Mexico *

Dr. Alex Jimenez DC, MSACP, CIFM, IFMCP, ATN, CCST
My Digital Business Card

Post Disclaimer

Professional Scope of Practice *

The information herein on "Revolutionizing Healthcare | El Paso, Tx (2023)" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card