Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Microbiome-Immune-Metabolic Axis: Inflammation and Obesity

Obesity is an impactful disease favored by multiple factors with no signs of abating. Despite massive health campaigns and multiple dietary, surgical and pharmacological options to treat obesity, this health problem is winning the battle. However, research has shown that many factors are left behind in previous obesity treatments, and studies in the gut microbiome show that the treatment focus should change. Despite an excessive calorie intake and lack of physical activity, the microbiome– immune-metabolic axis plays a crucial role in developing obesity since childhood. Resulting in dysbiosis, increasing the levels of inflammatory cytokines, consequently shifting the function of white and brown adipose tissue.

Obesity as a multifactorial disease:

Orthomolecular treatment focuses on preventing or reversing disease from the root. Finally, obesity is an excess of body fat caused by an elevated caloric intake and low physical activity. However, if we look closer, these two “simple” factors can heavily impact the microbiome-immune-metabolic axis contributing to inflammation.

Metabolic factors

Body fat excess: There are two types of fat, brown adipose tissue (BAT) and white adipose tissue (WAT). Consequently, these two types of fat have different functions in our body and interact with the microbiome-immune-metabolic axis.

  • BAT: This type of adipose tissue is abundant in childhood, and it especially expresses uncoupling protein 1 (UCP-1). In turn, UCP-1 has the specific function of uncoupling the electron transport chain to produce heat instead of ATP. This function results in heat production use to protect the essential organs in the children’s body. Also, BAT’s amount is associated with obesity prevention and weight reduction. BAT can be stimulated by many factors such as:
  1. Exposure to cold weather.
  2. Exercise.
  • WAT: White adipose tissue is fat’s principal storage, as adipocytes are mainly made of triglycerides. In addition, it has important influences on metabolism since it releases adipokines like adiponectin, resistin, and leptin. However, a WAT excess impacts metabolic function and increases the risk of developing chronic diseases such as Diabetes Mellitus by producing pro-inflammatory cytokines. 

In the presence of sedentarism and fat accumulation, WAT begins to replace BAT. Nevertheless, the influence of the microbiome-immune-metabolic axis remains unknown and needs further study.

Related Posts

Brown Adipose Tissue

Immune factors

Energy surplus and the immune reaction to infection: Infections and caloric intake are essential obesity influencers, acting bidirectionally and increasing obesity risk.

On the one hand, the immune cells use glucose caloric energy to release cytokines and cell proliferation and fight infections. On the other hand, however, when there is an energetic surplus and excessive fat tissue, adipocytes produce and release pro-inflammatory cytokines. The combination of these pro-inflammatory factors contributes to low-grade inflammation and insulin resistance in adipocytes, resulting in an adipocyte functional alteration. 

Another significant interaction is the one between macrophages and its stimulation on BAT’s UCP-1 expression. Furthermore, the conversion of WAT to BAT is increased by type 1 (M1) and type 2 cytokines (M2). The first one activates macrophages, and the latter polarizes macrophages to an alternative M2 state.

 

Microbiome 

In the past decade, many studies have reported the role of the gut’s microbiome and how it influences adiposity. Recent reports state that BAT and insulin sensitivity growth are higher in gut microbiome-depleted mouse models or germ-free mice. In addition, there existed high numbers of UCP-1 small lipid droplets in these animal models than in the control group.

Metabolites such as bile acids also play an essential role in balancing the gut’s microbiota. This balance characterizes by an increased number of Bacteroidetes and a lower number of Firmicutes. In turn, this B/F ratio reflects an environment where thermogenesis and proper glucose and lipid metabolism.

Prebiotics and other host-microbiome metabolites can impact the function and number of UCP-1 in BAT. Indeed, short-chain fatty acids supplementation can act like a browning agent on adipose tissue, resulting in BAT growth. In turn, and stimulates peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator (PGC)1α, which enhances fatty acid metabolism and upregulates UCP-1-mediated thermogenesis.

As human beings, we depend on a carefully organized environment. The Microbiome-Immune-Metabolic axis is an orchestrated interaction that needs a constant rearrangement. For instance, an acute disease can cause dysbiosis, and treatment with probiotics and prebiotics is the best way to bring homeostasis back. Also, the elimination diet can provide benefits by reducing the immune response, replenishing beneficial bacteria, and providing a better environment. The combination of these approaches can improve metabolic function by decreasing the inflammatory response. – Ana Paola Rodríguez Arciniega, MS

References:

Kincaid, Halle J et al. “Microbiome-immune-metabolic axis in the epidemic of childhood obesity: Evidence and opportunities.” Obesity reviews: an official journal of the International Association for the Study of Obesity vol. 21,2 (2020): e12963. doi:10.1111/obr.12963

Additional Online Links & Resources (Available 24/7)

 

Online Appointments or Consultations: bit.ly/Book-Online-Appointment

 

Online Physical Injury / Accident Intake Form: bit.ly/Fill-Out-Your-Online-History 

 

Online Functional Medicine Assessment: bit.ly/functionmed

 

General Disclaimer *

The information herein is not intended to replace a one-on-one relationship with a qualified healthcare professional or licensed physician and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. In addition, we provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed in: Texas & New Mexico*

 

 

Post Disclaimer

Professional Scope of Practice *

The information herein on "Microbiome-Immune-Metabolic Axis: Inflammation and Obesity" is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional.

Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.*

Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed in: Texas & New Mexico*

Again  We Welcome You¸

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training, and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists, and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, unwanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING!

Welcome & God Bless

EL PASO LOCATIONS

Central:
6440 Gateway East, Ste B
Phone: 915-850-0900

East Side:
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677A

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone
: (915) 850-0900
EmailSend Email
WebDrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
EmailSend Email
WebElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
EmailSend Email
WebChiropracticScientist.com

Push As Rx & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone
: (915) 412-6677
EmailSend Email
WebPushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone
: (915) 412-6677
EmailSend Email
WebPushAsRx.com

EVENTS REGISTRATION: Live Events & Webinars*

(Come Join Us & Register Today)

No Events Found

Call (915) 850-0900 Today!

Rated Top El Paso Doctor & Specialist by RateMD* | Years 2014, 2015, 2016, 2017, 2018, 2019, 2020 & 2021

Best Chiropractor In El Paso

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form:  bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment:  bit.ly/functionmed

Disclaimer *

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

phone: 915-850-0900

Licensed in Texas & New Mexico *

Post Disclaimer

Professional Scope of Practice *

The information herein on "Microbiome-Immune-Metabolic Axis: Inflammation and Obesity" is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional.

Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.*

Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed in: Texas & New Mexico*