Autoimmunity: One of the most common things is to leave the doctor’s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.
Table of Contents
Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?
The Exposome
Semin Arthritis Rheum. 2018; 47(5): 710?717.
Exposome Influence On SLE
The Ecology Of The Exposome
Exposome & The Alteration Of “Self”
The Exposome Connections To Autoimmune Diseases Converting Self Into Non?Self
- Immunometabolic dysfunctions through diet and lifestyle imbalances
- Gut Ecology and the Microbiome
- ViralorBacterialInfections
- Hormones
- Drugs
- Chemicals
- IonizingRadiation
- PsychologicalStress
FEBS Lett. 2017 Oct;591(19):3119?3134.
Cell. 2018 Jan 11;172(1?2):22?40.
Cross?Talk Among The Endocrine, Immune & Metabolic Systems
Multi?Organ Network Biology
In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH
Science. 2018; 360: 377?78. Dietary Influence?
Blocking Immune Cell Glycolysis & “Starving” Its Function
Ketogenic Diet’s Potential Impact On GAPDH Immunometabolic Regulation
Cell. 2018 Jan 11;172(1?2):162?175.
Front Immunol. 2017 Mar 21;8:311.
Origin Of IL?17 Producing Th17 Cells
What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?
www.cell.com/cell/issue?pii=S0092-8674(17)X0006-8%5B/caption%5D
Science. 2018 Mar 9;359(6380):1097?98.
Science. 2018 Mar 9;359(6380):1156?61.
Allergol Int. 2018 Jan 6;67(1):32?42.
Int J Mol Sci. 2015 Sep 1;16(9):20841?58.
Science. 2018 Mar 9;359(6380):1151?56.
High Fiber Influences On Diabetes In Animal Model
80% Of Patients With Autoimmune Disease Are Female
Why?
Estrogen & Autoimmunity
- The greatest association with autoimmune diseases is the female gender
- 17?beta estradiol seems to play a role in activating T cells in autoimmune disease
- T cells have ER?alpha receptors that are activated by 17?beta estradiol resulting in the production of inflammatory cytokines
- Blocking ER?alpha receptors may have a beneficial effect on autoimmune activation
Sci Signal. 2018 Apr 17;11(526). piieaap 9415
Eleanor Rogan, PhD IFM Linus Pauling Award Winner
www.JeffreyBland.com
Estrogen & Androgen Metabolism
4?Hydroxyestrogens & DNA reactivity
www.ncbi.nlm.nih.gov/pubmed/22155198%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/21432907%5B/caption%5D
Indole?3?Carbinol (I3C) Inhibition Of ER?Alpha
www.ncbi.nlm.nih.gov/pubmed/27312859%5B/caption%5D
Relationship Of Hepatic Drug Detoxification To Anti?Nuclear Antibody Development
onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780240805%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/24763537%5B/caption%5D
Biomed Res Int. 2015;2015:194031.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4365752/%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/18995849%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/24530186%5B/caption%5D
Making Friends With Ourselves: Clinical Implications
- Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
- – Dietary
- – Infection
- – Parasites
- – Xenobiotics
- – Hormone
- – Allergy
- – Specific medications
- – Dysbiosis
- Reduce exposure to DNA damage (radiation, chemicals)
- Support hepatic detoxification
- Implement gastrointestinal restoration program
- Reduce metabolic inflammation and endotoxin
- Reduce psychological stress factors that activate HPA axis
Jeffrey Bland, PhD
Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine
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