When the body is functioning properly, it is due to the hormones working on each organ and body system for individuals to achieve overall health and wellness. In males, the lead hormone is testosterone, and when hormones get off-balance it can cause problems to the male body. Hormones naturally decline due to age and chronic illnesses can also affect hormones causing individuals to be in pain and disrupting everyday activities. Part one explains what happens when there is low testosterone in male body and part two explains what are the causes for low testosterone. Over the last decade, many of our patients asked complex and insightful questions about hormone replacement therapies. By referring patients to qualified and skilled providers who specialized in hormone wellness services, we advise our patients, appropriately, to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Jimenez DC provides this information as an educational service only. Disclaimer
In older males, hormones naturally decline due to age and the testosterone levels start to get off-balance when there is an overproduction from the adrenal glands. With hormone replacement therapy or HRT, it can help regulate and replenish testosterone levels in the body. Not only that but HRT can even help prolong the progress of prostate cancer and lower the overproduction of androgen hormones from the adrenal glands.
New Guidelines Presented at the American Academy of Anti-Aging.
Erectile dysfunction is a common complaint that older males go through when they age. Testosterone replacement therapy or TRT shows promising potential by replenishing low testosterone levels and improving erectile dysfunction.
Since testosterone correlated with cognitive function, TRT improves it. High free testosterone, was associated with better performance on tests from memory, executive function, and spatial ability. Not only that, TRT can reduce the risk for Alzheimer’s and improve cerebral blood flow.
Alzheimer’s disease is a progressive neurological disorder that causes the brain to shrink and is one of the most common causes of dementia. Alzheimer’s can cause a person to decline their thinking, behavioral and social skills while also affecting their ability to function independently.
Testosterone Replacement Therapy can have a beneficial impact on males which includes:
Testosterone therapy created a more anti-inflammatory profile by lowering fewer inflammatory cytokines like TNF and IL-1 beta. TRT can cause the body to produce more anti-inflammatory cytokines like IL-10 and even help lower total cholesterol.
The guidelines recommend collecting an early-morning sample to compensate for the natural diurnal variation in testosterone levels. But for men 45 and older, this is unnecessary. About 2569 men at Minneapolis VA looked at testosterone levels based on age throughout the day. Only the youngest men (<45) had significant differences based on age and the different tests to detect testosterone deficiency include:
There are many methods of testosterone therapy for males that have low levels of testosterone. These include:
Transdermal Testosterone Patches are available in 2-mg and 4 mg preparations and the typical starting dose is 4-mg/day; can increase to 8-mg or decrease to 2 -mg as needed. What you need to do is:
Testosterone Gels are topical testosterone and can be applied in the morning to the shoulders, abdomen, or upper arm; preferably at the same location every day. What you need to do:
Injectable testosterone esters in oil are slowly absorbed from the lipid
phase. There are different esters absorb at various rates giving them different
The longer-acting esters may convert more readily to estrogen and peak levels after IM use are greater than topical use but so is peak-trough fluctuation. There are two types of testosterone injections, they’re are testosterone enanthate or cypionate injections. What these two injections do are:
The adverse effects are approved 3/2019 and have a BID formulation taken with food. The dosage is about 237 mg bid up to 396 mg bid (avail as 158, 198, and 237 mg soft gels). By taking testosterone undecanoate orally it is best to know that it can increase BP (Black box warning of the risk of
major cardiac events), it can bypass the liver because it is absorbed through lymphatic
circulation and it can avoid skin irritation (patches), transference (Topicals), pain (injections).
Testosterone Pellets can offer the longest duration of action with prolonged zero-order, steady-state characteristics. They can last 3 to 6 months depending on activity and stress level and are about 75mg per pellet and are measure 3.2 mm (1/8 inch) in diameter and approximately 9 mm in length.
Usages on testosterone pellets:
Clomiphene citrate is used off-label to attempt to increase sperm density in men with oligospermia or azoospermia and normal to low serum testosterone concentrations. Clomiphene is also used for testosterone deficiency in men who wish to preserve or improve fertility. Clomiphene is a weak estrogen receptor antagonist that stimulates increased pulsatile GnRH secretion from the hypothalamus and subsequent pituitary gonadotropin (FSH, LH) release. There have been multiple studies that suggest clomiphene citrate can improve semen parameters in patients with oligo-, oligo astheno-, and azoospermia. Clomiphene dosing includes:
Clomiphene side effects include:
HCG does not negatively impact fertility/sperm count as testosterone often does and does not cause testicular atrophy. Surprisingly it is identical to LH with some FSH activity stimulating testosterone production by the testicle. HCG Dosing includes:
HCG side effects and precautions include:
All in all, hormones play a functional role in the body. When there are unwanted pathogens that entered the body and cause harm it can lead the body to be off-balance. In this case with hormones, when the unwanted pathogens cause the body to overproduce hormones, it can cause chronic illnesses that can cause pain and affect a person’s overall health and wellness.
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The information herein on "The Latest Guidelines For Male Hormones | Part 3" is not intended to replace a one-on-one relationship with a qualified health care professional, or licensed physician, and is not medical advice. We encourage you to make your own healthcare decisions based on your research and partnership with a qualified healthcare professional.
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Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*
Licensed in: Texas & New Mexico*
Dr. Alex Jimenez DC, MSACP, CIFM*, IFMCP*, ATN*, CCST
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