Inflammation

Endocrine Disruptors: Obesity and PCOS

Share

Our daily routine is full of processes that expose us to different chemical toxins. Somewhere around the fact that we needed to preserve the storage life of our products with preservatives and additives, we forgot about how these products would affect our health. Our lifestyle habits are a combination of what we do, what we consume (dietary and information intake), and what we are exposed to in our environment. Nowadays, women’s (and sometimes men’s) daily beauty and hygiene routine exposes them to more than 250 chemicals compounds that might harm their hormone production. Furthermore, the connection between these endocrine disruptors, like bisphenols and parabens, with hormonal homeostasis and our endocrine health ultimately reflecting in metabolic and inflammatory disorders is well studied.

In addition to how these endocrine disruptors may exert a detrimental effect on hormone metabolism, production, and transport, we need to reflect on how a pro-inflammatory milieu and obesity can result in disorders like PCOS.

What are endocrine disruptors?

Endocrine disruptors are part of a diverse group of molecules that can be synthetic or natural. Either way, they all have the potential to inhibit, slow, or interfere with hormonal biosynthesis. The disruption of these chemicals can be present in control mechanisms, genetic expression, epigenetic manifestation, and hormone regulation. 

BPA

Furthermore, these endocrine disruptors (ED) are extensively distributed in hygiene, foods, plastic bottles, and cosmetic packages are commonly used in our daily life. One of the most common ED is bisphenol A (BPA), a phenolic structure that mimics estrogen’s chemical composition. This characteristic allows BPA to interact with estrogen receptors and interfere with hormonal homeostasis affecting female fertility. However, this interaction has been extensively studied, resulting in the utilization of alternative BPA replacement products like:

  • Bisphenol S (BPS)
  • Bisphenol F (BPF)
  • Bisphenol AF (BPAF)

Parabens

Parabens or p-hydroxybenzoic acid are distributed in our daily life products, and with BPA, they can add up to a “cocktail effect.” These parabens have anti-androgenic activity due to their binding capacity with androgen receptors, resulting in an inhibition of testosterone-induced transcription. The most common parabens are these following:

  • Methylparaben (MP)
  • Propylparaben (PP)
  • Ethylparaben (EP)
  • Butylparaben (BP)
  • Benzylparaben (benzylP)

Several studies have confirmed that parabens are associated with reproductive disruption, hormonal inhibition, and development stunt. Recently, MP has been related to the inhibition of energy-balancing hormones and metabolic health. Consequently, MP has been proposed as an ED with obesogenic potential.

Endocrine disruptors and PCOS mechanisms

Polycystic ovarian syndrome encompasses a myriad of dysfunctions, including metabolic, reproductive, and neuroendocrine disorders. Consequently, this condition is heavily influenced by excess body weight and insulin sensitivity. Furthermore, these two conditions work synergistically to develop PCOS pathophysiology. Firstly, obesity interferes with the ovulatory process; meanwhile, hyperinsulinemia promotes the conversion of androgens.

Adding to the metabolic mechanisms, obesity promotes a low-grade inflammatory environment where a proper ovarian function cannot thrive.

A study with the aim to determine the association and causation of environmental EDs and PCOS consisted of 19 women with PCOS and 20 healthy subjects. The results of this study reported that those patients diagnosed with PCOS had higher concentrations of BPA. Furthermore, these patients were divided between those with an average weight and their obese counterparts.

On the other hand, the interaction between testosterone and BPA resulted in an exciting PCOS pathology explanation. The mechanisms of action are as follow:

  1. Testosterone decreases uridine diphosphatase glucuronosyltransferase activity which leads to increased levels of BPA.
  2. BPA interferes with hydroxylases enzymatic action, which are crucial for testosterone metabolism.
  3. Also, BPA displaces testosterone to SHBG, increasing the concentration of circulating free androgen.

Hormonal balance depends on an intricate web of mechanisms. Starting from their production and transportation, EDs can interfere and cause detrimental effects that lead to hormonal dysfunction. Now more than ever, the term diet refers to what we consume, and refraining from BPA and parabens may contribute to the prevention of diseases like PCOS. Novel research also shows how parabens have obesogenic properties. Adding these factors and knowing how they interact, we can clearly say that eating clean and consuming clean is the only way to preserve proper hormonal function. – Ana Paola Rodríguez Arciniega, MS

References:

Šimková, M et al. “Endocrine disruptors, obesity, and cytokines – how relevant are they to PCOS?.” Physiological research vol. 69, Suppl 2 (2020): S279-S293. doi:10.33549/physiolres.934521

Additional Online Links & Resources (Available 24/7)

 

Online Appointments or Consultations: https://bit.ly/Book-Online-Appointment

 

Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History 

 

Online Functional Medicine Assessment: https://bit.ly/functionmed

 

Post Disclaimer

Professional Scope of Practice *

The information herein on "Endocrine Disruptors: Obesity and PCOS" is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional.

Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.*

Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed in: Texas & New Mexico*

Recent Posts

Spinal Imaging Back Pain Clinic Expectations

Chiropractors and spine specialists utilize spinal imaging through X-rays, MRIs, or CT scans to figure… Read More

August 4, 2021

Tinnitus and its Alternative Treatment

Tinnitus is defined as the perception of sound without an external acoustic stimulus. It is… Read More

August 4, 2021

Weight Training To Strengthen The Back Muscles

When back pain presents for a prolonged period, the back muscles reduce in mass but… Read More

August 3, 2021

Lifestyle Changes to Improve Hormonal Balance

Balance is the state of equilibrium; it means to have an equal distribution, and it… Read More

August 3, 2021

The Importance Of Sleeping On The Right Pillow

Many individuals do not realize the importance of the type of pillow they use for… Read More

August 2, 2021

Personal Injury, Trauma & Spine Rehab. Specialists

Online History & Registration 🔘
Call Us Today 🔘