Brain Inflammation and Fatigue in Functional Neurology


How often do you become fatigued when driving compared to in the past? Or how often do you become fatigued when reading compared to in the past? And, how often do you feel you are not getting enough sleep or rest? If you experience any of these problems often, you may be experiencing brain inflammation and fatigue due to a variety of health issues.


Chronic fatigue syndrome (CFS) and other similar health issues, such as Gulf War illness (GWI), share many common symptoms, several of which can include muscle pain and discomfort, fatigue, cognitive impairment, disrupted sleep, sore throat, headaches, and general malaise, typically after participating in any type of physical activity or exercise.


CFS has frequently been referred to as a mental health issue. In 2015, a National Academy of Medicine-led comprehensive overview of scientific literature and patients’ accounts cautioned that many healthcare professionals are doubtful about the seriousness of CFS, commonly mistaking it for a mental health issue or believe it a figment of the patient’s imagination.”


Moreover, the research study also supports that healthcare professionals should admit CFS as a health issue which needs diagnosis and treatment. The review also discussed what at the time was ultimately considered unknown causes of CFS.


Although important progress was developed in the manner that chronic fatigue syndrome (CFS) is diagnosed and perceived in the medical community, there’s currently no known treatment for the health issue and its causes still remain unknown.


New research studies, however, offer new hope for fast and precise diagnosis of the health issue, as changes in brain chemistry associated with inflammation and neurological diseases have been found. Between 836,000 and 2.5 million people in the United States suffer from CFS. The findings may also help people with CFS receive successful treatment.


Furthermore, one research study, which was directed by researchers at Georgetown University Medical Center in Washington, D.C., identified changes in brain chemistry that also exist in other similar health issues, such as GWI, a health issue which is ultimately believed to have affected approximately 175,000 war veterans returning from the Gulf War.


Analyzing the Brain in Chronic Fatigue Syndrome


Dr. James N. Baraniuk, a professor of medicine at Georgetown University School of Medicine, led the new research study, along with the findings which have been published in the journal Scientific Reports. Dr. Baraniuk and his group of researchers analyzed the cerebrospinal fluid of people with CFS and other health issues, such as GWI, in addition to healthy controls.


The group pulled the fluid with a lumbar puncture, before and after the individuals participated in a session of physical activity or exercise. The group additionally analyzed the brains of the individuals utilizing functional MRI (fMRI).


The physical activity or exercise sessions lasted for 25 minutes and consisted of riding a stationary bicycle. The bike immunity increased as predicted by their own era, so the participants reached 85 percent of their maximum heart rate.


Before participating in any physical activities or exercises, amounts of microRNA (miRNA), which are responsible for regulating protein generation, were exactly the exact same in all the individuals participating in the research study. However, 24 hours following the physical activities or exercises, this changed for the three distinct groups of participants.


Every class had a different pattern of modification. The researchers stated, “CFS had 12 diminished miRNAs following physical activity or exercise.” Despite symptom overlap of CFS, GWI and other health issues in their differential diagnosis, miRNA patterns in cerebrospinal fluid signaled different mechanisms for post-exertional malaise in CFS and GWI.


Additionally, the analysis also discovered miRNA changes in just two subtypes of GWI. Tachycardia that lasted for two to three days after the workout was developed by 1 subgroup. FMRI investigations revealed that these individuals had smaller brainstems in brain regions responsible for controlling the heartbeat. FMRI scans showed decreased brain activity.


Another GWI group, however, introduced neither modifications to heart rate nor brainstem atrophy, but its own associates appeared to need extra brain regions so as to do a memory task. Surprisingly, Dr. Baraniuk discussed that the miRNA changes found in such states were different from those observed in depression, fibromyalgia, and Alzheimer’s disease, among others.


“We certainly see three distinct patterns in the brain’s production of those molecules at the CFS group and both GWI phenotypes. This information will probably be well-received by individuals that suffer from such ailments that are misdiagnosed and rather may be medicated for depression or other psychological disorders,” stated Dr. James N. Baraniuk


New research studies have demonstrated that changes in brain chemistry associated with inflammation may cause fatigue. Health issues like chronic fatigue syndrome and Gulf War illness are believed to be caused by neuroinflammation and other molecule changes in the brain. In the following article, inflammation and fatigue, can be caused due to a variety of causes, although the causes still remain mostly unknown. Although fatigue may be a frustrating symptom, relief is possible with proper treatment. – Dr. Alex Jimenez D.C., C.C.S.T. Insight



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Has it become harder for you to learn new things? Or is your temperament generally getting worse? How often do you get fatigued after meals? If you’ve experienced any of these situations, you may have brain inflammation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .


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Additional Topic Discussion: Chronic Pain


Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.




Neural Zoomer Plus for Neurological Disease



Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual’s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.


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Professional Scope of Practice *

The information herein on "Brain Inflammation and Fatigue in Functional Neurology" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.


Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*


Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
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Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
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